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Descrição (Português)
Bupropiom ou bupropiona, previamente conhecida por anfebutamona, é um antidepressivo atípico que actua como inibidor da recapturação da dopamina e, mais fracamente, da noradrenalina. Também é um Antagonista nicotínico utilizado para tratar a dependência do tabaco. A Bupropiona pertence à classe química das aminoquetonas e tem uma estrutura parecida com a catinona estimulante, dietilcatinona anorética e fentilaminas em geral.
Sua introdução no mercado se deu relativamente cedo, porém foi retirado do mercado em 1985 nos EUA por induzir crises convulsivas nas doses que eram então utilizadas (doses significantemente maiores do que as atuais).
A bupropiona é um inibidor seletivo da recaptação da noradrenalina e da dopamina, com fraca ação na recaptação da serotonina, sem interferência com a monoaminoxidase. Acredita-se que seu mecanismo de ação esteja relacionado com a inibição dos mecanismos noradrenérgicos e dopaminérgicos. A bupropiona exibe ação antidepressiva e minimiza os sintomas da abstinência nicotínica.
O efeito da Bupropiona nos receptores nicotínicos do cérebro como antagonista, que produz em fumantes uma falta de vontade de fumar, como se já tivessem fumado, foi aproveitado e a Bupropiona foi aproveitada também como medicamento anti-tabaco quando foi re-lançada no mercado mundial.
Estudos atuais apontam que a Bupropiona é um anti-depressivo com eficácia comparável à maioria dos SSRIs, como a Fluoxetina e a Paroxetina, porém seu destaque maior se deve ao fato de não causar diminuição na libido, tanto em homens quanto em mulheres. Isso, e seu efeito terapêutico efetivo especialmente em depressão com fadiga, faz da Bupropiona uma boa opção no tratamento da depressão atualmente. As doses utilizadas atualmente não ultrapassam os 450mg, e os fabricantes advertem para os riscos de crises convulsivas caso sejam tomadas doses maiores.
Nas doses terapêuticas atualmente utilizadas, de 75mg a 450mg, a Bupropiona demonstrou ter a mesma incidência de crises convulsivas de outros antidepressivos atualmente comercializados como a Fluoxetina (Prozac), em torno de 0,01% a 0,1%.
A Bupropiona age como um bom antidepressivo sozinho mas é particularmente popular como uma medicação em conjunta nos casos em que a resposta com os antidepressivos SSRI não é a desejada, ou em pacientes que sofrem perda drástica de libido durante o tratamento com outros antidepressivos, especialmente SSRIs.
Em contraste com muitas drogas psiquiátricas, incluindo quase todos os antidepressivos, a bupropiona não causa aumento de peso ou disfunção sexual.
As reacções adversas que esta substância pode provocar são: insónia, tremor, ansiedade, enxaqueca, hipertensão, perda de peso, irritabilidade, hipersudação, ondas de calor, sensação de calor no corpo.
Contra-Indicações e precauções ao uso desta substância: Enfarte de miocárdio recente.
Só deve ser utilizada por indicação médica.
Note: Your account will be debited in USD when you
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Other brand names of Wellbutrin SR are Zyban, Bupropion, Amfebutamone.
Why do some drugs have different names?
These are trade or brand names registered by the manufacturer. In different countries manufacturers will often use different trade names. The medications have the same active ingredients, but may look different and have a different trade name.
Brand names: Wellbutrin XL, Wellbutrin SR, Wellbutrin
Why is Wellbutrin SR prescribed?
Wellbutrin is prescribed to help relieve major depression. Symptoms include a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and sometimes, suicidal thoughts or behavior.
Wellbutrin is thought to work by altering levels of the brain chemicals norepinephrine and dopamine. It is not chemically related to other antidepressants such as tricyclics (Elavil), MAO inhibitors (Nardil, Parnate), or serotonin re-uptake inhibitors (Paxil and Prozac).
Most important fact about Wellbutrin SR
Wellbutrin is associated with an increased risk of seizures. This risk is greater at higher doses (approximately 4 in 1,000 patients at dosages of 300 to 450 milligrams a day). Certain factors increase the risk of seizure, including:
— A history of head trauma or previous seizure
— Central nervous system tumor
— Severe liver disease such as cirrhosis
— A history of eating disorders, including anorexia and bulimia
— Excessive use of alcohol, or abrupt withdrawal from alcohol or sedatives
— Taking medications that lower the seizure threshold (see «Possible food and drug interactions when taking Wellbutrin SR»)
To minimize the risk of seizures, dose increases should be done gradually, and the total daily dose of Wellbutrin should not exceed 450 milligrams. Additionally, the doctor should be aware of all your medical conditions, and you should not take any other medications (both prescription and over-the-counter) unless the doctor approves.
How should you take Wellbutrin SR?
Take Wellbutrin exactly as prescribed by your doctor. The usual dosing regimen is 3 equal doses spaced evenly throughout the day. Allow at least 6 hours between doses. Your doctor will probably start you at a low dosage and gradually increase it; this helps minimize side effects.
You should take Wellbutrin SR, the sustained-release form, in 2 doses, at least 8 hours apart. Wellbutrin XL extended-release tablets should be taken once a day in the morning. Swallow Wellbutrin SR and Wellbutrin XL tablets whole; do not chew, divide, or crush them.
If Wellbutrin works for you, your doctor will probably have you continue taking it for at least several months.
If you miss a dose...
Take it as soon as you remember. If it is within 4 hours of your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
Storage instructions...
Store at room temperature. Protect from light and moisture.
What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Wellbutrin.
Side effects of Wellbutrin SR may include:
Agitation, constipation, dizziness, dry mouth, insomnia, nausea, rash, sweating, weight loss
Why should Wellbutrin SR not be prescribed?
Do not take Wellbutrin if you are sensitive to or have ever had an allergic reaction to it.
Since Wellbutrin causes seizures in some people, do not take it if you have any type of seizure disorder or if you are taking another medication containing bupropion, such as Zyban, the used to help quit smoking. If you have a seizure while taking Wellbutrin, stop taking the drug and never take it again.
Do not take Wellbutrin while abruptly giving up alcohol or sedatives, including tranquilizers such as Librium, Valium, and Xanax. Rapid withdrawal increases the risk of seizures.
If you have had any kind of heart trouble or liver or kidney disease, be sure your doctor knows about it before you start taking Wellbutrin SR. It must be used with extreme caution if you have severe cirrhosis of the liver. A reduced dosage may be needed if you have any sort of liver or kidney problem.
You should not take Wellbutrin if you currently have, or formerly had, an eating disorder. For some reason, people with a history of anorexia nervosa or bulimia seem to be more likely to experience Wellbutrin-related seizures. Do not take Wellbutrin if, within the past 14 days, you have taken a monoamine oxidase inhibitor (MAO inhibitor) drug, such as the antidepressants Marplan, Nardil or Parnate. This particular drug combination could cause you to experience a sudden, dangerous rise in blood pressure.
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